Main Information
- Drug : Drostanolone Enanthate
- What is : A synthetic androgen, or male hormone, similar to testosterone
- Concentrarion : 200mg / ml
- Package : 10ml Vial
- Excipients : Benzyl Benzoate, Benzyl Alcohol, Cottonseed oil
- Aspect : Clear, yellowish liquid
- Pharmaceutical form : Sterile oily solution
- Administrarion : Deep intramuscular injection
Synonyms
- Masteron
- Drolban
- Masteril
- Drostanolon
Descripition
A sterile oily solution containing per mL: Drostanolone Enanthate 200 mg with Benzyl Alcohol as preservative, Benzyl Benzoate solubilizer, in Cottonseed Oil q.s.
Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
- Pharmacodynamic : Drostanolone is a synthetic androgen, or male hormone, similar to testosterone. Drostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
- Mechanism of action : Drostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, drostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Indications
For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Hormonal treatment is part of the complex therapy for some kind of tumors, particularly the ones associated with hormone-active tissues like breast or prostate cancer. Some types of breast cancer cells, expressing estrogen receptors (called ER+ cancers), use estrogen for their growth and dissemination. That is why drugs that block estrogen receptors or decrease their expression on the cell membrane- anti-estrogens- could limit the tumor spread and size. As it has lower androgenic rate compared to testosterone, the risk of virilization is much lighter. Due to this fact, women, who usually do not respond well to any anabolic steroids, were having much greater chance to survive cancer. Drostanolone can also be used for breast tumors that do not respond well to other treatments or also as palliative care for advanced incurable tumors. The effects of the product depend of course on the dose and period of administration. The risk of virilization becomes greater with high doses and continuous administration period.
Contraindications
Drostanolone is contraindicated in conditions like:
- Hepatic diseases
- Carcinoma of male breast
- Prostate cancer
- Cardiac disease
Drug Interactions
When administered concurrently, the following drugs may interact with androgens :
- Anticoagulants, oral : C-17 substituted derivatives of testosterone, have been reported to decrease the anticoagulant requirement. Patients receiving oral anticoagulant therapy require close monitoring especially when androgens are started or stopped.
- Antidiabetic drugs and insulin : In diabetic patients, the metabolic effects of androgens may decrease blood glucose and insulin requirements.
- ACTH and corticosteroids : Enhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with hepatic or cardiac disease.
- Oxyphenbutazone : Elevated serum levels of oxyphenbutazone may result.
Dosage
The medicinal use of this product has become obsolete for decades. Therefore, there are no studies or information on dosage. Only your doctor can prescribe the dosage and the form of application. If your goal is to increase athletic performance, it is recommended to read the overview section on our website.
Adverse Reactions
The severe or irreversible adverse reactions of Drostanolone, which give rise to further complications including:
- Accelerated alopecia
- Acne
- Clitoromegaly
- Coarser skin
- Deepening of voice
- Facial hair
- Hoarseness
- HDL cholesterol decrease
- LDL cholesterol increase
- Virilization
As drostanolone does not aromatize at any dose, typical estrogen-linked side effects encountered when using other anabolic steroids, like water retention, gynecomastia, and elevated blood pressure are not observed.
As drostanolone also suppresses natural testosterone production, additional testosterone therapy and post-cycle therapy should be considered.
Storage
Slowdrol should be stored at 20° to 25°C (68° to 77°F).
Warming and rotating the vial between the palms of the hands will redissolve any crystals that may have formed during storage at low temperatures.
History
Drostanolone Enanthate is strictly an underground anabolic androgenic steroid that is based on the discontinued Drostanolone Propionate compound known as Masteron. Masteron is a fairly old anabolic steroid first created in 1959 by Syntex and has been sold under several other brand names such as Masteril, Drolban and Metormon with Masteron remaining the most recognizable.
During the 1970's and 80's Masteron enjoyed significant therapeutic success, particularly in the treatment of inoperable breast cancer. Despite its success in cancer treatment and other areas of medicine, in the late 1980's and early 1990's Masteron began to disappear from the U.S. and European markets and in modern times is no longer manufactured. Drostanolone is still an FDA approved anabolic steroid, but no U.S. pharmacy manufactures it.
During the 1970's and heavily in the 1980's Masteron become very popular among competitive bodybuilders. In fact, it has come to be viewed as an essential for contest prep for many bodybuilders and is a common favorite among recreational bodybuilders during their cutting cycles. Due to the Propionate ester that is attached Masteron must be injected at minimum three times per week with an every other day schedule being the most efficient. Because of the need for frequent injections and high demand for the steroid, many underground labs began manufacturing the Drostanolone hormone with the Enanthate ester attached. The new combination become very prominent in the early 2000's and as such Drostanolone Enanthate was born. Drostanolone Enanthate is the same anabolic steroid as Drostanolone Propionate; the hormone itself has not been changed. The only difference in the two compounds is the attached ester, which affects the drug's active life and release into the body.
Functions
Drostanolone Enanthate is a dihydrotestosterone (DHT) based anabolic steroid. Drostanolone is simply the DHT hormone structurally altered. The alteration exists through the addition of a methyl group at carbon position 2. This ensures the hormone doesn't suffer metabolic breakdown brought on by the 3-hydroxysteroid dehydrogenase enzyme found in the skeletal muscle. This simple structural change also makes the hormone far more anabolic, and that gives us Drostanolone. Once the hormone has been created, altered from DHT, an ester is then attached, and in this case the ester attached is Enanthate. Enanthate is not a steroid or a drug but nothing more than a timing tool used for a drug.
As with Drostanolone Propionate, Drostanolone Enanthate is well known for being one of the only anabolic steroids that carries strong anti-estrogenic properties. This anabolic steroid cannot increase estrogen levels; in fact, it can actually decrease estrogen levels in the body. It is for this reason Drostanolone was successful in breast cancer treatment with the combination of Drostanolone and Tamoxifen being very commonplace for many years. Bodybuilders welcome this trait due to estrogen often being difficult to control with many steroids and lower estrogen levels often leading to a harder and more defined look during the cutting phase.
Drostanolone Enanthate possesses some of the most misleading anabolic and androgenic ratings of any anabolic steroid, although not nearly as misleading as Halotestin and Anavar. Drostanolone has a binding affinity to the androgen receptor that is five times greater than testosterone, which not only produces a harder look it can also have a positive impact on fat loss. All anabolic steroids can help improve the metabolic rate, but those with a strong androgen binding affinity can have an impact on direct lipolysis.
Effects
For the full positive effects of Drostanolone Enanthate to be seen a lean physique will show them best. This means the prime time for this steroid will be during a cutting cycle, and the leaner the individual is the more pronounced the effects will be. For the competitive bodybuilder undergoing a 12-16 week prep, you will find Drostanolone most commonly shows up in the latter half of prep once a significant amount of fat has been removed. The addition of the Drostanolone hormone may help him lose a little bit of the fat that's still hanging on but more importantly it will ensure his physique possess the hard look that's desired.
For the recreational bodybuilder or steroid user, one that's not going to be as lean as a competitive bodybuilder, Drostanolone Enanthate is still a good choice for a cutting cycle. You may not end up as hard as the competitive bodybuilder due to not being quite as lean but hardness will appear nonetheless. However, if there is a significant layer of fat coving the body it may be very hard to find any noticeable benefit in terms of hardness and definition. This truly is a steroid that works best when already lean in regards to hardness.
While lean use is the best use for hardening it is not the only use for this anabolic steroid. Drostanolone Enanthate is a good choice for the athlete looking for a boost in strength and more so than often given credit for. Most steroid users only use Drostanolone when cutting, when calories are low and strength is necessarily diminished. But for an athlete looking for a boost in strength with little to no weight gain, this can be a solid choice. The athlete should also find improvements in recovery and muscular endurance, and regardless of the end goal recovery and endurance are both invaluable.
We're then left with bulking use and while any anabolic steroid can be used for bulking Drostanolone Enanthate is perhaps one of the worst choices. The Drostanolone hormone doesn't pack the punch needed for significant growth. Some growth may occur especially with a very high dose but there are far better options. There are those that will include low to moderate amounts of Drostanolone Enanthate in their cycle for the anti-estrogen benefits during the bulking phase, but when we're talking about a bulking cycle that often includes high doses of testosterone this will not be enough to combat the aromatase induced estrogenic activity.
Side Effects
Drostanolone Enanthate is a relatively side effect friendly anabolic steroid. There are numerous possible side effects of Drostanolone Enanthate, but compared to many anabolic steroids it falls into the semi-mild category. Most men will find this steroid to be well tolerated and even with some females. Virilization symptoms can be strong but controllable with the right plan. A female athlete can make good use of the Drostanolone hormone, but she will need to be careful. In order to understand the side effects of Drostanolone Enanthate and what can be done we have broken them down into their respective categories below.
- Estrogenic : Drostanolone Enanthate does not carry or possess any estrogenic related side effects. Gynecomastia and water retention are impossible with this anabolic steroid. Anti-estrogens are not needed due to this steroid's use but that does not mean they won't be needed at all depending on the other steroids that may or may not be used with it. In some cases, those who implement a stack that's not full of heavy aromatizers and who aren't sensitive to estrogenic side effects may find the anti-estrogenic effect of Drostanolone Enanthate to be enough.
- Androgenic : The side effects of Drostanolone Enanthate can and primarily surround those of an androgenic nature. The androgenic side effects of Drostanolone Enanthate may include acne, hair loss in men predisposed to male pattern baldness and body hair growth. Despite a potent binding relationship to the androgen receptor the total androgenic activity should not be extreme and such side effects should not be extreme. If you are predisposed to male pattern baldness this steroid is well known for speeding up hair loss and should be avoided if that is a concern. If you are not predisposed hair loss is impossible.
Important Note: the 5-alpha reductase enzyme, the enzyme that reduces testosterone to DHT, does not metabolize Drostanolone. There is no reduction; it's already DHT. Because no reduction exists there is nothing to inhibit or block and this means 5-alpha reductase inhibitors like Finasteride will do nothing to combat androgenic effects.
Drostanolone Enanthate can also promote virilization symptoms in women. Virilization refers to the promotion of male characteristics in women, specifically body hair growth, a deepening of the vocal chords and clitoral enlargement. It is very possible to use this steroid without these issues, although genetic sensitivity will play a role. If symptoms begin to show simply discontinue use and they will rapidly go away. It is when virilization symptoms are allowed to set in that they become a problem and in some cases irreversible.
Important note: Female users of Drostanolone will be best served by choosing Drostanolone Propionate as it will clear the body faster should issues arise.
- Cardiovascular : The Drostanolone hormone can have a significant negative impact on cholesterol. Drostanolone Enanthate may increase LDL (bad cholesterol) and decrease HDL (good cholesterol). The impact on HDL is often much greater than the impact on LDL. The impact on LDL may or may not be significant. The total impact on cholesterol will not be as strong as it is with C17-alpha alkylated steroids (most oral steroids). However, the total impact can be much greater than compared to steroids like Testosterone or Nandrolone. Elevated blood pressure is also possible but not common.
Cholesterol management is very important when using the Drostanolone hormone. If you suffer from high cholesterol you will want to avoid this anabolic steroid. If you are healthy enough for use, maintaining a cholesterol friendly lifestyle is very important. A healthy diet with plenty of omega fatty acids and one that is low in simple sugars and saturated fats is a good place to start. Regular cardiovascular activity is also important, even if it's simply taking a walk.
- Testosterone : Drostanolone Enanthate will suppress natural testosterone production. The use of exogenous testosterone in all male Drostanolone users is imperative if they are to avoid a low testosterone condition. A low testosterone condition will carry numerous symptoms as well as it is extremely unhealthy. A standard TRT (testosterone replacement therapy) dose of testosterone is enough to remedy the suppression problem. This does not mean more cannot be used, but at minimum 100mg per week will be needed in most cases.
Once the use of Drostanolone Enanthate has ended and the hormone along with any and all other steroidal compounds has cleared the body, natural testosterone production will begin again. Pre-use levels will not return overnight; it will take several months for this to occur. Post Cycle Therapy (PCT) plans are generally recommended in order to boost production and increase the odds of recovery.
Important note: Natural testosterone recovery assumes no preexisting low testosterone condition existed before the use of anabolic steroids. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) due to improper or irresponsible anabolic steroid use.
- Hepatotoxicity : Drostanolone Enanthate is not toxic to the liver and cannot cause damage or stress to this primary organ.
Administration
Most men will dose Masterol (Propionate version) at 300-400mg per week. Because the Enanthate ester is larger than the Propionate ester this means it takes up more space in the total compound. Dosing may need to be adjusted upwards to garner the same amount of active Drostanolone when using the Enanthate version. An increase by 100mg per week should do the trick. Regardless of the dose, the total weekly dose may be split into two equal size injections per week, such as one on Monday and one on Thursday. Total use will last anywhere from 6-12 weeks depending on need.
Because of the potential for virilization recommended doses of Drostanolone Enanthate are not provided for women. Propionate versions are the only ones women should consider. Please see the Masterol profile for related information.
Reviews
Drostanolone Enanthate is a quality anabolic steroid and a great choice for a cutting cycle. However, if we were to rank it next to the Propionate version the Propionate version would win out. This is not because of the effectiveness of the two forms but the Propionate version is easier to control and there is more quality Drostanolone Propionate on the market.
Unfortunately Drostanolone (any form) often gets an unappreciated rating by some steroid users but this is because it's not fully understood. Some steroid users gauge a steroid's power only by what it can do in terms of adding raw size. If this is the only way you gauge a steroid it's true Drostanolone will be disappointing. But if you can understand the importance and benefits outside of bulking that can exists with various steroids the Drostanolone hormone is one that's in the top 20 if not the top 10.
Profile
- Base : Drostanolone
- Ester : Enanthate
- Chemical name :
- Molecular Weight (base) : 304.474
- Molecular Weight (ester) : 112.172
- Formula : C27H44O3
- Effective Dose (Men) : 400mg to 500mg/week
- Effective Dose (Women) : 50 to 100mg/week
- Active life : 8 days
- Detection Time : 3 months
- Anabolic/ Androgenic ratio : 62:25
