Main Information

• Drug : A blend of 4 esters of Testosterone
• Testosterone Propionate : 30mg/ml
• Testosterone Phenylpropionate : 60mg/ml
• Testosterone Isocaproate : 60mg/ml
• Testosterone Decanoate : 100mg/ml
• What is : A manufactured version of the naturally occurring male sex hormone, testosterone.
• Concentrarion : 250mg / ml
• Package : 10ml Vial
• Excipients : Benzyl Benzoate, Benzyl Alcohol, Cottonseed oil
• Aspect : Clear, yellowish liquid
• Pharmaceutical form : Oily solution
• Administrarion : Deep intramuscular injection

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Synonyms

• Durateston
• Durandrone Forte
• Sustanon prolongatum
• Sustanon 250
• Prarbolan

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Descripition

Sustan 250 is a clear pale yellow solution for injection containing the active ingredient testosterone (250 mg/ml) in 4 separate forms. The active substances of Sustan 250 are turned into testosterone by your body.

Testosterone is an endogenous androgen wich inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.

Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement; vocal chord thickening; alterations in body musculature; and fat distribution.

Androgens also cause retention of nitrogen, sodium, potassium, and phosphorus, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

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Indications

Males

Sustan 250 is indicated for replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone.

• Primary hypogonadism (congenital or acquired) : Testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy.
• Hypogonadotropic hypogonadism (congenital or acquired) : Gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation. (Appropriate adrenal cortical and thyroid hormone replacement therapy are still necessary, however, and are actually of primary importance.)
  
  If the above conditions occur prior to puberty, androgen replacement therapy will be needed during the adolescent years for development of secondary sexual characteristics. Prolonged androgen treatment will be required to maintain sexual characteristics in these and other males who develop testosterone deficiency after puberty.
  
  Safety and efficacy of Sustan 250 in men with age-related hypogonadism have not been established.
• Delayed puberty : Sustan 250 may be used to stimulate puberty in carefully selected males with clearly delayed puberty. These patients usually have a familial pattern of delayed puberty that is not secondary to a pathological disorder; puberty is expected to occur spontaneously at a relatively late date. Brief treatment with conservative doses may occasionally be justified in these patients if they do not respond to psychological support. The potential adverse effect on bone maturation should be discussed with the patient and parents prior to androgen administration. An X-ray of the hand and wrist to determine bone age should be obtained every six months to assess the effect of treatment on the epiphyseal centers (see WARNINGS).

Females

• Metastatic mammary cancer : Sustan 250 may be used secondarily in women with advancing inoperable metastatic (skeletal) mammary cancer who are one to five years postmenopausal. Primary goals of therapy in these women include ablation of the ovaries. Other methods of counteracting estrogen activity are adrenalectomy, hypophysectomy, and/or antiestrogen therapy. This treatment has also been used in premenopausal women with breast cancer who have benefited from oophorectomy and are considered to have a hormone-responsive tumor. Judgment concerning androgen therapy should be made by an oncologist with expertise in this field.

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Contraindications

Breast Cancer in a Male Patient, cancer of the prostate gland, polycythemia vera, increased calcium in the blood from cancer, Diabetes, high cholesterol, Overweight, high blood pressure, Heart Attack, lung embolism, Chronic Heart Failure, Stroke, Blood Clot Formation in Veins, Chronic Lung Disease, Liver Problems, kidney disease with reduction in kidney function, Enlarged Prostate, Enlarged Breasts, Temporarily Stops Breathing While Sleeping, Visible Water Retention, Pregnancy, A Mother who is Producing Milk and Breastfeeding, Abnormal Increase in Red Blood Cells

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Drug Interactions

When administered concurrently, the following drugs may interact with androgens :

• Anticoagulants, oral : C-17 substituted derivatives of testosterone, have been reported to decrease the anticoagulant requirement. Patients receiving oral anticoagulant therapy require close monitoring especially when androgens are started or stopped.
• Antidiabetic drugs and insulin : In diabetic patients, the metabolic effects of androgens may decrease blood glucose and insulin requirements.
• ACTH and corticosteroids : Enhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with hepatic or cardiac disease.
• Oxyphenbutazone : Elevated serum levels of oxyphenbutazone may result.

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Dosage

Dosage and duration of therapy with Sustan 250 will depend on age, sex, diagnosis, patient's response to treatment, and appearance of adverse effects. When properly given, injections of Sustan 250, are well tolerated. Care should be taken to slowly inject the preparation deeply into the gluteal muscle, being sure to follow the usual precautions for intramuscular administration, such as the avoidance of intravascular injection.

In general, total doses above 400 mg per month are not required because of the prolonged action of the preparation. Injections more frequently than every two weeks are rarely indicated.

• Male hypogonadism : As replacement therapy, i.e., for eunuchism, the suggested dosage is 50 to 400 mg every 2 to 4 weeks.
• In males with delayed puberty : Various dosage regimens have been used; some call for lower dosages initially with gradual increases as puberty progresses, with or without a decrease to maintenance levels. Other regimens call for higher dosage to induce pubertal changes and lower dosage for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. Dosage is within the range of 50 to 200 mg every 2 to 4 weeks for a limited duration, for example, 4 to 6 months. X-rays should be taken at appropriate intervals to determine the amount of bone maturation and skeletal development .
• Palliation of inoperable mammary cancer in women : A dosage of 200 to 400 mg every 2 to 4 weeks is recommended. Women with metastatic breast carcinoma must be followed closely because androgen therapy occasionally appears to accelerate the disease.

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Adverse Reactions

• Skin and Appendages : Hirsutism, male pattern baldness, and acne.
• Cardiovascular Disorders : Myocardial infarction, stroke.
• Fluid and Electrolyte Disturbances : Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
• Gastrointestinal : Nausea, cholestatic jaundice, alterations in liver function tests; rarely, hepatocellular neoplasms, peliosis hepatis.
• Hematologic : Suppression of clotting factors II, V, VII, and X; bleeding in patients on concomitant anticoagulant therapy; polycythemia.
• Nervous System : Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
• Metabolic : Increased serum cholesterol.
• Vascular Disorders : Venous thromboembolism.
• Other : Anaphylactoid reactions; inflammation and pain at injection site.
• Female : The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman, androgens cause virilization of the external genitalia of the female fetus.
• Male : Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

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Storage

Sustan 250 should be stored at 20° to 25°C (68° to 77°F).

Warming and rotating the vial between the palms of the hands will redissolve any crystals that may have formed during storage at low temperatures.

History

Sustan 250 is without question the most popular testosterone mixture on the planet. Where most testosterone compounds are single ester compounds, Sustan 250 is comprised of four distinct esters; four distinct testosterone compounds conjoined into one. Developed by Organon, unter the brand name of Sustanon, for the purpose of infrequent Testosterone Replacement Therapy (TRT) treatment, while effective it would soon be held as vital to many performance enhancing athletes; after all, Organon has for years manufactured some of the best anabolic steroids on earth.

When it comes to Sustanon's original intent, the idea was to create a testosterone compound comprised of varying sized esters that would allow for instant testosterone benefits that would be long lasting. Of course, this hope would prove to be successful; in-fact, a TRT patient could actually remedy his low testosterone condition with only one injection of Sustan 250 every three to four weeks. Even so, due to a mixture of small and large esters, a problem was later discovered; while low testosterone would be remedied, total testosterone levels would rise and fall beyond appropriate or satisfactory means. For this reason, if levels are to be maintained at a more stable level, one injection every teen to fourteen days is probably more efficient, and for this reason, many U.S. physicians often opt for large single ester testosterone compounds like Testosterone Cypionate.

While the original intent of Sustan 250 was for TRT, this can be an excellent choice for performance enhancing athletes; after all, Sustan 250 is merely testosterone. Even so, due to the mixture of four varying esters, if levels are to remain not only stable but also peaked at all times, despite large esters being a part of the compound every other day injections are normally recommended. You might be able to get by with three injections per week, but an every other day schedule will prove far more efficient. With all of this in mind, we want to look at Sustan 250 , what it is precisely, what it has to offer, the side effects associated, and of course, what you can do about them in-order to achieve successful supplementation.

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Functions

As stated above, Sustan 250 is a four part testosterone mixture; specifically it is comprised of Testosterone Propionate, Testosterone Phenylpropionate, Testosterone Isocaproate and Testosterone Decanoate. Through this mixture, the Propionate and Phenylpropionate esters represent the small esters and will provide fast acting testosterone benefits while the Decanoate ester, a truly massive ester will ensure the benefits are long lasting; the Isocaproate ester fills the role in the middle. Of course, its not enough for these esters to be conjoined together, in-order for Sustan 250 to exist they must be conjoined together in a precise manner; otherwise, it is not Sustan 250.

The precise composition of Sustan 250 is as follows:

• 30mg/ml Testosterone Propionate
• 60mg/ml Testosterone Phenylpropionate
• 60mg/ml Testosterone Isocaproate
• 100mg/ml Testosterone Decanoate

If you come across a product claiming to be Sustan 250, if it is not comprised exactly as listed above, if it carries varying esters or even the same esters at different doses it is not Sustan 250; the above is what defines and separates this testosterone form. As a testosterone compound, in many ways everything that can be said of all single ester testosterone compounds can be said of Sustan 250; in the end, it all comes down to personal preference. At any rate, as a pure testosterone compound, Sustan 250 carries an anabolic and androgenic rating of 100 in both categories, and is a highly versatile steroidal hormone. Identical to the testosterone you naturally produce, Sustan 250 carries all the sexually related traits and plays intrinsic roles on our sexual and physical health and to a degree even our general state of mind and overall well-being.

A compound that has the ability to greatly enhance protein synthesis, this is important as protein is the building block of muscle tissue and synthesis represent the rate by-which cells build proteins. Further, Sust as its often called will enhance nitrogen retention in the muscle tissue; all lean muscle tissue is comprised of 16% nitrogen, and the more we retain the more anabolic we remain; our anabolic atmosphere is enhanced. While these two factors are primary and important traits, Sust is not done yet. Often ignored but truly valuable is this hormones ability to increase the production and release of Insulin-Like Growth Factor-1 (IGF-1). IGF-1 is highly anabolic, a peptide hormone produced by all human beings and it plays important roles revolving around our total recovery; in-fact, IGF-1 will affect nearly every cell in the human body.

Enhanced protein synthesis, nitrogen retention and IGF-1 are all important factors, but Sustan 250 continues to not disappoint. Through supplementation, red blood cell count is increased, and as red blood cells carry oxygen to and through the blood this results in greater blood oxygenation. Then we have glucocorticoid suppression; simply put, the suppression and reduction of stress hormones. These nasty hormones, cortisol being the most well-known are in many ways the opposite of anabolic hormones in that they destroy muscle tissue and promote fat gain; Sustan 250 will see such hormones suppressed.

A hormone that aromatizes heavily, like all testosterone compounds Sustan 250 can lead to adverse estrogen effects. Further, due to its heavy androgenic activity, this is a steroid that cannot be recommended to women or virilization will occur. Absolutely, women need testosterone, and they can suffer from low testosterone, but if therapeutic treatment is needed a single ester compound is easier to control. As for performance enhancement, the doses necessary to promote such performance will always lead to some level of virilization and on this basis other steroids must be chosen; specifically steroids that possess low androgenic activity and low virilization ratings.

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Effects

Testosterone Replacement Therapy Benefits of Sustan 250 : When it comes to Testosterone Replacement Therapy, the benefits of Sustan 250 are fairly straightforward; your testosterone levels are low, Sust is pure testosterone, and through administration the problem is solved. Through supplementation, each and every last symptom of low testosterone can and will be reversed, and as a result, your overall quality of life enhanced. Those who suffer from low testosterone often find their libido is severely diminished and often erectile dysfunction becomes a problem, but these are hardly the only symptoms. A loss of muscle mass and strength is often common as is increased body-fat, and this can all occur despite proper exercise and dieting habits. Further, those who suffer often find their energy levels drained, they become depressed, suffer from insomnia and their immune system weakens; not to mention they suffer from a lack of mental clarity and open the door to many far more serious conditions. When low testosterone is ignored, it has been shown to be a contributor to leading to diabetes, osteoporosis and even Alzheimers disease. Thankfully, if you suffer from low levels, Sustan 250 can ensure you suffer no more, and the odds of you falling prey to the more serious conditions will be greatly improved.

Performance Benefits of Sustan 250 : In many ways, there is a lot of crossover as it pertains to TRT and performance based supplementation of Sustan 250, but in this case, were referring to supraphysiological doses. In a TRT plan, we are supplementing with testosterone in-order to bring our levels back to normal, but with performance the idea is to increase them beyond what can normally be achieved in-order for more testosterone to be available to do what testosterone does best. In any case, when it comes to the performance benefits of Sustan 250, they can largely be broken down into three categories, bulking, cutting and overall enhancement.

Bulking : With supplementation and adequate calories present, you will be able to gain more lean mass as well as see your strength increase. Further, due to the metabolic enhancing properties of testosterone, you will be able to do so with less body-fat accumulation that normally accompanies mass gaining phases.

Cutting : When it comes to the cutting cycle, many often think of other steroids before they think of Sustan 250 or any testosterone compound, but exogenous testosterone can be essential to a successful plan. Through use, you will ensure you preserve as much lean tissue as possible while calories are restricted, and this is invaluable. When we diet, in-order to lose body-fat our caloric intake must be at a deficit level; we must burn more calories than we consume in-order to burn body-fat. As a result, lean tissue is often lost, but Sust will protect it, and the more lean tissue you hold onto the more fat you'll burn. Couple this with testosterones metabolic enhancing properties and you're a fat burning machine. Overall Enhancement: regardless of your purpose of use, bulking, cutting or to simply enhance athletic performance, you will find Sustan 250 is one of the most versatile steroidal compounds on earth. Regardless of your purpose of use, your muscular endurance will be enhanced as will your overall rate of recovery, and those two traits alone make this a steroid worthy of consideration. When we look at all these benefits and how testosterone affects the body in its every day functional sense, the benefits of Sustan 250 as you can see are truly vast.

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Side Effects

As a heavily aromatizing steroid, the primary side-effects of Sustan 250 will be those of an estrogenic nature as the aromatase process refers to the conversion of testosterone into estrogen. As estrogen levels increase, this can lead to gynecomastia and excess water retention, which can in-turn promote high blood pressure. For this reason, its often advised that the use of an Aromatase Inhibitor (AI) be present with the use of any testosterone compound; Anastrozole (Arimidex) and Letrozole (Femara) are always your best choices. By their natural mode of action, AIs will inhibit the aromatase process from occurring and even lower the bodys total estrogen levels; problem solved. It should be noted; Selective Estrogen Receptor Modulators (SERMs) can also protect against gynecomastia by binding to the receptors in the place of estrogen; however, they will not inhibit aromatase or reduce estrogen levels. This means SERMs cannot offer protection beyond gynecomastia, and depending on your dosing and overall sensitivity they may not be enough to protect you from that; AIs are the only true answer.

While AIs can offer a lot of protection, and with supraphysiological doses of testosterone they're often recommended, they can have a negative impact on your lipid profiles as can supraphysiological doses of testosterone to a degree. Its not uncommon to see LDL levels increase and HDL levels decrease, but all hope is not lost. For this reason, it is imperative you do not supplement if you have high cholesterol, but if healthy you should give extra effort into ensuring the continuation of such healthy levels. A great place to start is with the consumption of plenty of omega fatty acids as they will increase your HDL levels, which will in-turn regulate your LDL levels.

Important Notes on Sustan 250 Side-Effects:

• You should not supplement if you have high blood pressure.
• You should not supplement it you have high cholesterol.
• You should not supplement if you suffer from prostate enlargement.
• You should not supplement if youre not a healthy adult male.

Weve already looked at blood pressure and cholesterol, and while prostate enlargement is unlikely with testosterone use, it is possible, and the problem could be exasperated if you already suffer. The testosterone hormone has the ability to convert into dihydrotestosterone (DHT), the androgen that causes prostate enlargement, but it takes a massive DHT buildup for a healthy prostate to fall prey. Further, DHT buildups of a massive nature can induce hair-loss in men who are predisposed to male-pattern baldness; however, if you are predisposed you were going to lose your hair anyway.

It must be noted; when it comes to the side effects of Sustan 250, TRT patients rarely have a large concern; after all, theyre merely replacing, they are not enhancing. With TRT level doses, we are not presenting a hormone we are unfamiliar with or surpassing levels our body is unaccustomed to; once again, we are merely replacing what we are lacking with a hormone we are very familiar with. Then we have adolescent use, and in no way can such use be recommended unless under severe therapeutic need due to the damage it could cause to a fragile and underdeveloped androgen system.

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Profile

• Base : Testosterone
• Esters : Propionate , Phenylpropionate, Isocaproate, Decanoate
• Chemical Name : 17b-hydroxy-4-androsten-3-one
• Formula (base) : C27 H40 O3
• Molecular Weight (base) : 288.429
• Molecular Weight, Esters :
  • Propionate : 362.5082
  • Phenylpropionate : 438.6058
  • Isocaproate : 404.5886
  • Decanoate : 460.6958
• Formula (base) : C19 H28 O2
• Melting Point (base) : 155
• Effective Dose (Men) : 500-2000mg/ week
• Effective Dose (Women) : Not recommended
• Active life : Up to 3 weeks
• Detection Time : 3+ months
• Anabolic/Androgenic ratio : 100/100