Main Information
- Drug : Drostanolone Propionate
- What is : A synthetic androgen, or male hormone, similar to testosterone
- Concentrarion : 100mg / ml
- Package : 10ml Vial
- Excipients : Benzyl Benzoate, Benzyl Alcohol, Cottonseed oil
- Aspect : Clear, yellowish liquid
- Pharmaceutical form : Sterile oily solution
- Administrarion : Deep intramuscular injection
Synonyms
- Masteron
- Drolban
- Masteril
- Drostanolon
Descripition
A sterile oily solution containing per mL: Drostanolone Propionate 100 mg with Benzyl Alcohol as preservative, Benzyl Benzoate solubilizer, in Cottonseed Oil q.s.
Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
- Pharmacodynamic : Drostanolone is a synthetic androgen, or male hormone, similar to testosterone. Drostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
- Mechanism of action : Drostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, drostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Indications
For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Hormonal treatment is part of the complex therapy for some kind of tumors, particularly the ones associated with hormone-active tissues like breast or prostate cancer. Some types of breast cancer cells, expressing estrogen receptors (called ER+ cancers), use estrogen for their growth and dissemination. That is why drugs that block estrogen receptors or decrease their expression on the cell membrane- anti-estrogens- could limit the tumor spread and size. As it has lower androgenic rate compared to testosterone, the risk of virilization is much lighter. Due to this fact, women, who usually do not respond well to any anabolic steroids, were having much greater chance to survive cancer. Drostanolone can also be used for breast tumors that do not respond well to other treatments or also as palliative care for advanced incurable tumors. The effects of the product depend of course on the dose and period of administration. The risk of virilization becomes greater with high doses and continuous administration period.
Contraindications
Drostanolone is contraindicated in conditions like:
- Hepatic diseases
- Carcinoma of male breast
- Prostate cancer
- Cardiac disease
Drug Interactions
When administered concurrently, the following drugs may interact with androgens :
- Anticoagulants, oral : C-17 substituted derivatives of testosterone, have been reported to decrease the anticoagulant requirement. Patients receiving oral anticoagulant therapy require close monitoring especially when androgens are started or stopped.
- Antidiabetic drugs and insulin : In diabetic patients, the metabolic effects of androgens may decrease blood glucose and insulin requirements.
- ACTH and corticosteroids : Enhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with hepatic or cardiac disease.
- Oxyphenbutazone : Elevated serum levels of oxyphenbutazone may result.
Dosage
The medicinal use of this product has become obsolete for decades. Therefore, there are no studies or information on dosage. Only your doctor can prescribe the dosage and the form of application. If your goal is to increase athletic performance, it is recommended to read the overview section on our website.
Adverse Reactions
The severe or irreversible adverse reactions of Drostanolone, which give rise to further complications including:
- Accelerated alopecia
- Acne
- Clitoromegaly
- Coarser skin
- Deepening of voice
- Facial hair
- Hoarseness
- HDL cholesterol decrease
- LDL cholesterol increase
- Virilization
As drostanolone does not aromatize at any dose, typical estrogen-linked side effects encountered when using other anabolic steroids, like water retention, gynecomastia, and elevated blood pressure are not observed.
As drostanolone also suppresses natural testosterone production, additional testosterone therapy and post-cycle therapy should be considered.
Storage
Masterol should be stored at 20° to 25°C (68° to 77°F).
Warming and rotating the vial between the palms of the hands will redissolve any crystals that may have formed during storage at low temperatures.
History
Drostanolone Propionate is an anabolic androgenic steroid that first hit the market around 1970 under the trade name Masteron manufactured by Syntex. However, the compound was actually developed by Syntex in 1959 along with Oxymetholone (Anadrol) but would not be released until well after Anadrol. Syntex would also provide the compound under numerous other brand names such as Masteril and Metormon among others, as well as Drolban under the license given by Syntext to Lilly. However, Masteron has remained the most recognizable brand.
As a therapeutic agent, Drostanolone enjoyed two decades of success in combating advanced inoperable breast cancer in postmenopausal women. It would also become a popular cutting steroid among bodybuilders, which is where Drostanolone is currently most commonly found. However, the original Masteron brand is no longer available; in fact, nearly every pharmaceutical brand on earth has been discontinued. This compound is still approved by the U.S. FDA, but it is rarely used in breast cancer treatment any longer in favor of other options. The steroid is, however, still tremendously popular in competitive bodybuilding cycles and often considered essential to contest preparation.
Functions
Drostanolone Propionate is a dihydrotestosterone (DHT) derived anabolic steroid. Specifically, Drostanolone is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle. It also greatly increases the hormone's anabolic nature. This simple structural change is all it takes to create Drostanolone, and from here the small/short Propionate ester is attached in order to control the hormone's release time. Drostanolone Enanthate can also be found through some underground labs, which does not have to be injected as frequently, but it is somewhat rare compared to the Propionate version. The majority of all Drostanolone on the market will be Drostanolone Propionate.
On a functional basis, Drostanolone is well-known for being one of the only anabolic steroids with strong anti-estrogenic properties. Not only does this steroid carry no estrogenic activity, but it can actually act as an anti-estrogen in the body. This is why it has been effective in the treatment of breast cancer. In fact, the combination of Drostanolone and Nolvadex (Tamoxifen Citrate) has been shown to be far more effective than chemotherapy in the treatment of inoperable breast cancer in postmenopausal women. This also makes it a popular steroid among bodybuilders as it could actually prohibit the need for an anti-estrogen when used in the right cycle. This will also prove advantageous during the cutting phase due to the hardening effects it can provide.
Drostanolone carries relatively low anabolic and androgenic ratings; however, these ratings are somewhat misleading. It's important to remember DHT, the basis of Drostanolone, is five times more androgenic than testosterone with a much stronger binding affinity to the androgen receptor. This again promotes a harder look and can also enhance fat loss. Most all anabolic steroids are well-noted for enhancing the metabolic rate, but strong androgens have a tendency to directly promote lipolysis.
As an anabolic, Drostanolone isn't well-known for promoting gains in lean muscle mass. It has never been used for muscle wasting in a therapeutic sense and will almost always be found in cutting plans among performance athletes. It can, however, promote significant boosts in strength, which could prove beneficial to an athlete who may not necessarily be looking for raw mass.
Effects
Without question, the effects of Drostanolone will be displayed in the most efficient way during a cutting cycle. However, for the effects to be truly appreciated the individual will need to be extremely lean. This is why the hormone will most commonly be found at the end of bodybuilding contest prep cycles as the individual should already be fairly lean at this stage. The added Drostanolone will help him lose that last bit of fat that often hangs on for dear life at the end of a cycle. It will also ensure his physique appears as hard as can be. Of course, the anti-estrogenic effect will simply enhance this overall look. For those that are not competitive bodybuilder lean, it is possible that the effects of Drostanolone may not be all that noticeable. The individual who is under 10% body fat should be able to notice some results and produce a harder, dryer look, but much over 10% and the effects may not be all that pronounced.
As a potent androgen, Drostanolone can benefit the athlete looking for a boost in strength. This can be a very beneficial steroid for an athlete who is following a calorie restricted diet in an effort to maintain a specific bodyweight necessary for his pursuit. The individual could easily enjoy moderate increases in strength and a slight improvement in recovery and muscular endurance without unwanted body weight gain.
As a bulking agent, the effects of Drostanolone will prove to be rather week. It is possible the hormone could provide gains in mass similar to Primobolan Depot, which won't be that strong either, if the total dose was high enough. However, the relative gain in size will be very moderate with many anabolic steroids being far more suited for this period of steroidal supplementation. There are those who may wish to include Drostanolone in a bulking plan for its anti-estrogenic and fat loss effects. The latter would ensure they kept their body fat gain minimized during off-season bulking phases, but this isn't reason enough to use it in this phase. Body fat should be controllable without it. As for the anti-estrogenic effects, off-season cycles are normally comprised of large amounts of aromatase activity due to high doses of testosterone. Progesterone activity is also commonly high with the addition of Nandrolone compounds and possible Trenbolone. Consider additional Anadrol or Dianabol and this estrogenic activity can become very pronounced. Unfortunately, while possessing anti-estrogenic effects, Drostanolone will not be strong enough to combat this level of estrogenic activity.
Side Effects
In many ways, Drostanolone is a fairly side effect friendly anabolic steroid. Side effects of Drostanolone use most certainly exist, but most men will find this steroid highly tolerable. As for females, virilization symptoms can be strong with this steroid, but we will also find they can be managed with the right plan. In order to understand the side effects of Drostanolone, we have broken them down into their separate categories along with all you need to know.
- Estrogenic : Drostanolone does not aromatize and it does not carry any progestin nature making estrogenic side effects impossible with this steroid. This means gynecomastia and water retention will not be concerns. It also means high blood pressure that is sometimes caused by excess water retention will not be a concern. An anti-estrogen is not needed due to this steroid's use; as discussed it can have anti-estrogenic effects itself. However, depending on the specific cycle/stack that's implemented, an anti-estrogen may be needed.
- Androgenic : The side effects of Drostanolone can include those of an androgenic nature. Androgenic side effects can include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Thankfully this hormone carries a moderate level of total androgenic activity despite being a direct derivative of the potent androgen DHT. However, individual sensitivity will play a strong role, this steroid is well-known for greatly enhancing male pattern baldness in sensitive men far more than many anabolic steroids.
An important note; the Drostanolone hormone is not metabolized by the 5-alpha reductase enzyme. This is the enzyme responsible for reducing testosterone to dihydrotestosterone. In the case of Drostanolone, it's already DHT; there is no reduction. As there is no reduction, there is no metabolism and nothing to inhibit. This means the androgenic nature of Drostanolone will not be strongly affected by a 5-alpha reductase inhibitor such as Finasteride.
Due to its androgenic nature, Drostanolone can produce virilization symptoms in women. Virilization symptoms can include body hair growth, a deepening of the vocal chords and clitoral enlargement. Virilization symptoms have been well-noted in breast cancer treatment plans, but this is normally due to the necessary high doses used to treat such a condition. In a performance capacity, it should be possible to use this steroid without related symptoms with a low dose. However, while individual response will dictate quite a bit, this will not be a primary recommended steroid for female athletes. If it is used and related symptoms begin to show, discontinue use immediately and they will fade away. If the symptoms are ignored, it is very possible they may set in and become irreversible.
- Cardiovascular : Drostanolone can have a significant effect on cholesterol. This can result in an increase in LDL cholesterol, as well as a decrease in HDL cholesterol with the strongest emphasis on the latter. The total affect on cholesterol will not be as strong as often found in many oral steroids, specifically C17-alpha alkylated steroids. However, the total affect on cholesterol management will be stronger than compared to Nandrolone compounds or the testosterone hormone. It is also possible that Drostanolone could have a slight negative impact on blood pressure, but this will be a non-issue for most.
Due to the cholesterol effects of Drostanolone, cholesterol management becomes very important with this steroid. Far more important than with basic testosterone cycles or stacks including a basic 19-nor. If you already suffer from high cholesterol you should not use this anabolic steroid. If you are healthy enough for use, maintaining a cholesterol friendly lifestyle is very important. Not only does this mean a healthy diet, but it should be one that includes plenty of omega fatty acids, is limited in saturated fats as well as simple sugars. Plenty of cardiovascular activity is also advised.
- Testosterone : Drostanolone will significantly suppress natural testosterone production making exogenous testosterone therapy important when using this steroid. Failure to include exogenous testosterone will lead most men to a low testosterone condition, which not only comes with numerous possible symptoms but is also extremely unhealthy.
As most will use Drostanolone in a cutting cycle, it's very common not to want to use a lot of testosterone due to the high levels of estrogenic activity it can provide. If this is the case, you will find a low dose of 100-200mg per week of testosterone to be enough to combat suppression and give you the needed testosterone.
Once Drostanolone is discontinued and all exogenous steroidal hormones have cleared your system, natural testosterone production will begin again. Prior levels will not return to normal over night, this will take several months. Due to the slow recovery, Post Cycle Therapy (PCT) plans are often recommended. This will speed up the recovery greatly; however, it won't bring your levels back to their peak, this will still take time. A PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise and significantly cut down on the total recovery time. This natural recovery does assume no prior low testosterone condition existed. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper supplementation practices.
- Hepatotoxicity : Drostanolone is not a hepatotoxic anabolic androgenic steroid and will present no stress or damage to the liver.
Administration
The standard Drostanolone dose for adult men will normally fall in the 300-400mg per week range. Normally, this will mean an injection of 100mg every other day for a total of 6-8 weeks. This does not mean 6-8 weeks represents the total cycle, but this is a common time frame for the Drostanolone portion of a stack. Some may alternatively choose to split their dose up into a daily injection schedule, but every other day should suffice. If a Drostanolone Enanthate version is found, 1-2 injections per week will work, but such a version is somewhat rare.
For female breast cancer treatment, standard dosing calls for 100mg three times per weeks for 8-12 weeks. This will commonly lead to virilization symptoms that could be hard to reverse. However, no one can deny it's still better than cancer. For the female athlete, 50mg per week should be more than enough for a total of 4-6 weeks. Some women may find doses closer to 100mg per week to be justified if they tolerate the hormone well. Doses of this range should be controllable for most women, but individual sensitivity must be kept in mind. Doses that go above the 100mg per week mark or beyond 4-6 weeks of use will more than likely produce virilization symptoms at some level.
Reviews
In some performance enhancing circles, Drostanolone is viewed as a relatively weak anabolic steroid. This is largely due to the steroid having low mass promotion abilities, and many tend to equate quality steroids to their mass promotion characteristics. Some also tend to forget that while a steroid may be a quality one, it will not present notable benefits unless you are very lean. This tends to lead many to having a skewed perception of Drostanolone due to this improper thinking. This is a very valuable anabolic steroid, but you must understand the purpose of use and the benefits it can provide if such beneficial rewards are going to be gained. Understand that raw mass promotion is not the end all be all of progress; understand the total purpose of use of a steroid and when to use it and you will find Drostanolone to be a very valuable anabolic steroid.
Profile
- Base : Drostanolone
- Ester : Propionate
- Chemical name : [17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one propionate]
- Molecular Weight (base) : 304.474
- Molecular Weight (ester) : 74.079
- Formula : C23H36O3
- Manufacturer : Syntex (originally), Various Underground Labs
- Effective Dose (Men) : 350mgs/week (*100mgs Every other day) to 500mgs/week
- Effective Dose (Women) : 50-100mg/week
- Active life : 2-3 days
- Detection Time : 3 weeks
- Anabolic/ Androgenic ratio : 62:25
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